https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Midway through his vocation, Cees Dekker reinvented himself. Immediately after several years of hardcore physics, he shifted his concentrate to ‘nanobiology’ within the switch of the millennium. A phrase he coined himself, to be a issue of point.
1996, to start with mesoscopic charge density waves products; and first electrical measurements on an individual metallic nanocluster between nanoelectrodes
Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
I am able to rarely consider how I, for a geneticist, would manage to study elementary physics, let alone compete at the best. How did you go about this?
2010, designed a completely new way (‘wedging transfer’) to manipulate nanostructures; initial report of DNA translocation by means of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores
Case in point (three) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim of the pore is highlighted in purple, as well as a 3D rendering from the movement in the DNA rod is exhibited.
Several relevant developments adopted, wherever our team founded distinctive transistor variants such as single-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled several transistors into tiny proof-of-principle electronic circuits.
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim from the pore is highlighted in pink, as well as a 3D rendering of the movement from the DNA rod is shown.
The rotors harness Strength from a nanoscale h2o and ion stream which is generated by a static chemical or electrochemical opportunity gradient while in the nanopore, which can be established via a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Manage and function autonomously in physiological conditions, suggesting tips on how to setting up energy-transducing motors at nanoscale interfaces.
Resolving the move sizing in condensin-pushed DNA loop extrusion identifies ATP binding as being the move-building system
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‘That issues the artificial mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those days and determined about 5 hundred genes which are minimally expected to get a operating mobile. We want to search base-up: how can we transfer from the couple molecules to a complete biological process?
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; ceesdekker.net discovery of lengthy-array conformational modifications in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in the nanopore
The biophysicist from Delft – who continues to be Just about the most cited researchers within the Netherlands For many years – takes his obligation to add on the clarification and popularisation of his function at the border of physics and biology extremely very seriously and on a regular basis appears within the media; Otherwise to look at his operate, then about the relationship between science and his Christian religion.